diff --git a/libpod/container_internal_common.go b/libpod/container_internal_common.go
index 05a36e49b8..9e93188fd3 100644
--- a/libpod/container_internal_common.go
+++ b/libpod/container_internal_common.go
@@ -1993,10 +1993,21 @@ func (c *Container) generateResolvConf() error {
 		return err
 	}
 
+	networkBackend := c.runtime.config.Network.NetworkBackend
 	nameservers := make([]string, 0, len(c.runtime.config.Containers.DNSServers)+len(c.config.DNSServer))
-	nameservers = append(nameservers, c.runtime.config.Containers.DNSServers...)
-	for _, ip := range c.config.DNSServer {
-		nameservers = append(nameservers, ip.String())
+
+	// If NetworkBackend is `netavark` do not populate `/etc/resolv.conf`
+	// with custom dns server since after https://github.com/containers/netavark/pull/452
+	// netavark will always set required `nameservers` in statsBlock and libpod
+	// will correctly populate `networkNameServers`. Also see https://github.com/containers/podman/issues/16172
+
+	// Exception: Populate `/etc/resolv.conf` if container is not connected to any network
+	// ( i.e len(netStatus)==0 ) since in such case netavark is not invoked at all.
+	if networkBackend != string(types.Netavark) || len(netStatus) == 0 {
+		nameservers = append(nameservers, c.runtime.config.Containers.DNSServers...)
+		for _, ip := range c.config.DNSServer {
+			nameservers = append(nameservers, ip.String())
+		}
 	}
 	// If the user provided dns, it trumps all; then dns masq; then resolv.conf
 	var search []string
diff --git a/test/e2e/run_networking_test.go b/test/e2e/run_networking_test.go
index 3880fbc5b5..9bb2eac3c7 100644
--- a/test/e2e/run_networking_test.go
+++ b/test/e2e/run_networking_test.go
@@ -126,6 +126,37 @@ var _ = Describe("Podman run networking", func() {
 		Expect(session).Should(Exit(0))
 	})
 
+	It("podman verify resolv.conf with --dns + --network", func() {
+		// Following test is only functional with netavark and aardvark
+		// since new behaviour depends upon output from of statusBlock
+		SkipIfCNI(podmanTest)
+		net := createNetworkName("IntTest")
+		session := podmanTest.Podman([]string{"network", "create", net})
+		session.WaitWithDefaultTimeout()
+		defer podmanTest.removeNetwork(net)
+		Expect(session).Should(Exit(0))
+
+		session = podmanTest.Podman([]string{"run", "--name", "con1", "--dns", "1.1.1.1", "--network", net, ALPINE, "cat", "/etc/resolv.conf"})
+		session.WaitWithDefaultTimeout()
+		Expect(session).Should(Exit(0))
+		// Must not contain custom dns server in containers
+		// `/etc/resolv.conf` since custom dns-server is
+		// already expected to be present and processed by
+		// Podman's DNS resolver i.e ( aarvark-dns or dnsname ).
+		Expect(session.OutputToString()).ToNot(ContainSubstring("nameserver 1.1.1.1"))
+		// But /etc/resolve.conf must contain othe nameserver
+		// i.e dns server configured for network.
+		Expect(session.OutputToString()).To(ContainSubstring("nameserver"))
+
+		session = podmanTest.Podman([]string{"run", "--name", "con2", "--dns", "1.1.1.1", ALPINE, "cat", "/etc/resolv.conf"})
+		session.WaitWithDefaultTimeout()
+		Expect(session).Should(Exit(0))
+		// All the networks being used by following container
+		// don't have dns_enabled in such scenario `/etc/resolv.conf`
+		// must contain nameserver which were specified via `--dns`.
+		Expect(session.OutputToString()).To(ContainSubstring("nameserver 1.1.1.1"))
+	})
+
 	It("podman run network expose port 222", func() {
 		SkipIfRootless("iptables is not supported for rootless users")
 		session := podmanTest.Podman([]string{"run", "-dt", "--expose", "222-223", "-P", ALPINE, "/bin/sh"})