diff --git a/changes/sdk/pr.249.gh.OpenXR-SDK-Source.md b/changes/sdk/pr.249.gh.OpenXR-SDK-Source.md
new file mode 100644
index 000000000..3ef0d63f8
--- /dev/null
+++ b/changes/sdk/pr.249.gh.OpenXR-SDK-Source.md
@@ -0,0 +1,4 @@
+---
+- issue.231.gh.OpenXR-SDK-Source
+---
+loader: Fix building OpenXR-SDK with CMake's multi-config Ninja generator.
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index a09d63605..cec8f5ccf 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -419,10 +419,16 @@ set(GENERATED_OUTPUT)
 set(GENERATED_DEPENDS)
 run_xr_xml_generate(utility_source_generator.py xr_generated_dispatch_table.h)
 run_xr_xml_generate(utility_source_generator.py xr_generated_dispatch_table.c)
-add_custom_target(xr_global_generated_files DEPENDS ${GENERATED_DEPENDS})
+if(GENERATED_DEPENDS)
+    add_custom_target(xr_global_generated_files DEPENDS ${GENERATED_DEPENDS})
+else()
+    add_custom_target(xr_global_generated_files)
+endif()
+
 set_target_properties(xr_global_generated_files PROPERTIES FOLDER ${CODEGEN_FOLDER})
 
 set(COMMON_GENERATED_OUTPUT ${GENERATED_OUTPUT})
+set(COMMON_GENERATED_DEPENDS ${GENERATED_DEPENDS})
 if(NOT MSVC)
     include(CheckCXXCompilerFlag)
     include(CheckCCompilerFlag)
diff --git a/src/loader/CMakeLists.txt b/src/loader/CMakeLists.txt
index b386fb90d..8638bc6a6 100644
--- a/src/loader/CMakeLists.txt
+++ b/src/loader/CMakeLists.txt
@@ -31,6 +31,7 @@ endif()
 # List of all files externally generated outside of the loader that the loader
 # needs to build with.
 set(LOADER_EXTERNAL_GEN_FILES ${COMMON_GENERATED_OUTPUT})
+set(LOADER_EXTERNAL_GEN_DEPENDS ${COMMON_GENERATED_DEPENDS})
 run_xr_xml_generate(loader_source_generator.py xr_generated_loader.hpp)
 run_xr_xml_generate(loader_source_generator.py xr_generated_loader.cpp)
 
@@ -86,7 +87,9 @@ else()
 endif()
 set_target_properties(openxr_loader PROPERTIES FOLDER ${LOADER_FOLDER})
 
-set_source_files_properties(${LOADER_EXTERNAL_GEN_FILES} PROPERTIES GENERATED TRUE)
+if(LOADER_EXTERNAL_GEN_DEPENDS)
+    set_source_files_properties(${LOADER_EXTERNAL_GEN_DEPENDS} PROPERTIES GENERATED TRUE)
+endif()
 add_dependencies(openxr_loader generate_openxr_header xr_global_generated_files)
 target_include_directories(
     openxr_loader