diff --git a/base/tuple.jl b/base/tuple.jl
index 9c03274f190bf..339aafac171b1 100644
--- a/base/tuple.jl
+++ b/base/tuple.jl
@@ -596,7 +596,7 @@ any(x::Tuple{Bool, Bool}) = x[1]|x[2]
 any(x::Tuple{Bool, Bool, Bool}) = x[1]|x[2]|x[3]
 
 # a version of `in` esp. for NamedTuple, to make it pure, and not compiled for each tuple length
-function sym_in(x::Symbol, @nospecialize itr::Tuple{Vararg{Symbol}})
+function sym_in(x::Symbol, itr::Tuple{Vararg{Symbol}})
     @noinline
     @_total_meta
     for y in itr
@@ -604,7 +604,7 @@ function sym_in(x::Symbol, @nospecialize itr::Tuple{Vararg{Symbol}})
     end
     return false
 end
-in(x::Symbol, @nospecialize itr::Tuple{Vararg{Symbol}}) = sym_in(x, itr)
+in(x::Symbol, itr::Tuple{Vararg{Symbol}}) = sym_in(x, itr)
 
 
 """
diff --git a/test/namedtuple.jl b/test/namedtuple.jl
index babc61f267cc9..20737d68db1bb 100644
--- a/test/namedtuple.jl
+++ b/test/namedtuple.jl
@@ -406,3 +406,23 @@ let a = Base.NamedTuple{(:a, :b), Tuple{Any, Any}}((1, 2)), b = Base.NamedTuple{
     @test typeof(Base.merge(a, b)) == Base.NamedTuple{(:a, :b), Tuple{Any, Float64}}
     @test typeof(Base.structdiff(a, b)) == Base.NamedTuple{(:a,), Tuple{Any}}
 end
+
+function mergewith51009(combine, a::NamedTuple{an}, b::NamedTuple{bn}) where {an, bn}
+    names = Base.merge_names(an, bn)
+    NamedTuple{names}(ntuple(Val{nfields(names)}()) do i
+                          n = getfield(names, i)
+                          if Base.sym_in(n, an)
+                              if Base.sym_in(n, bn)
+                                  combine(getfield(a, n), getfield(b, n))
+                              else
+                                  getfield(a, n)
+                              end
+                          else
+                              getfield(b, n)
+                          end
+                      end)
+end
+let c = (a=1, b=2),
+    d = (b=3, c=(d=1,))
+    @test @inferred(mergewith51009((x,y)->y, c, d)) === (a = 1, b = 3, c = (d = 1,))
+end
diff --git a/test/tuple.jl b/test/tuple.jl
index 8ff311928b6b8..b806667fd9d0a 100644
--- a/test/tuple.jl
+++ b/test/tuple.jl
@@ -763,6 +763,12 @@ g42457(a, b) = Base.isequal(a, b) ? 1 : 2.0
 # issue #46049: setindex(::Tuple) regression
 @inferred Base.setindex((1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16), 42, 1)
 
+# issue #50562
+f50562(r) = in(:i_backward, r[])
+r50562 = Ref((:b_back, :foofakgka, :i_backw))
+f50562(r50562)
+@test @allocated(f50562(r50562)) == 0
+
 # issue #47326
 function fun1_47326(args...)
     head..., tail = args