diff --git a/base/inference.jl b/base/inference.jl
index 5479eb5ca91f9d..41f8a33ebddd0f 100644
--- a/base/inference.jl
+++ b/base/inference.jl
@@ -5217,6 +5217,23 @@ function occurs_outside_getfield(e::ANY, sym::ANY,
         if head === :(=)
             return occurs_outside_getfield(e.args[2], sym, sv,
                                            field_count, field_names)
+        elseif head === :foreigncall
+            args = e.args
+            nccallargs = args[5]::Int
+            # Only arguments escape, GC root arguments do not escape.
+            for i in 1:length(args)
+                a = args[i]
+                if i > 5 + nccallargs && symequal(a, sym)
+                    ty = widenconst(exprtype(a, sv.src, sv.mod))
+                    if isleaftype(ty) && nfields(ty) <= field_count
+                        continue
+                    end
+                    return true
+                end
+                if occurs_outside_getfield(a, sym, sv, field_count, field_names)
+                    return true
+                end
+            end
         else
             if (head === :block && isa(sym, Slot) &&
                 sv.src.slotflags[slot_id(sym)] & Slot_UsedUndef == 0)
@@ -5800,8 +5817,11 @@ end
 function replace_getfield!(e::Expr, tupname, vals, field_names, sv::InferenceState)
     for i = 1:length(e.args)
         a = e.args[i]
-        if isa(a,Expr) && is_known_call(a, getfield, sv.src, sv.mod) &&
-            symequal(a.args[2],tupname)
+        if !isa(a, Expr)
+            continue
+        end
+        a = a::Expr
+        if is_known_call(a, getfield, sv.src, sv.mod) && symequal(a.args[2], tupname)
             idx = if isa(a.args[3], Int)
                 a.args[3]
             else
@@ -5830,8 +5850,22 @@ function replace_getfield!(e::Expr, tupname, vals, field_names, sv::InferenceSta
                 end
             end
             e.args[i] = val
-        elseif isa(a, Expr)
-            replace_getfield!(a::Expr, tupname, vals, field_names, sv)
+        else
+            if a.head === :foreigncall
+                args = a.args
+                nccallargs = args[5]::Int
+                le = length(args)
+                next_i = 6 + nccallargs
+                while next_i <= le
+                    i = next_i
+                    next_i += 1
+
+                    symequal(args[i], tupname) || continue
+                    splice!(args, i, vals)
+                    next_i += length(vals) - 1
+                end
+            end
+            replace_getfield!(a, tupname, vals, field_names, sv)
         end
     end
 end
diff --git a/test/codegen.jl b/test/codegen.jl
index da80ff1661f039..96397a5651d3f0 100644
--- a/test/codegen.jl
+++ b/test/codegen.jl
@@ -128,10 +128,21 @@ function compare_large_struct(a)
     end
 end
 
+mutable struct MutableStruct
+    a::Int
+    MutableStruct() = new()
+end
+
+breakpoint_mutable(a::MutableStruct) = ccall(:jl_breakpoint, Void, (Ref{MutableStruct},), a)
+
 if opt_level > 0
     @test !contains(get_llvm(isequal, Tuple{Nullable{BigFloat}, Nullable{BigFloat}}), "%gcframe")
     @test !contains(get_llvm(pointer_not_safepoint, Tuple{}), "%gcframe")
     compare_large_struct_ir = get_llvm(compare_large_struct, Tuple{typeof(create_ref_struct())})
     @test contains(compare_large_struct_ir, "call i32 @memcmp")
     @test !contains(compare_large_struct_ir, "%gcframe")
+    breakpoint_mutable_ir = get_llvm(breakpoint_mutable, Tuple{MutableStruct})
+    @test !contains(breakpoint_mutable_ir, "%gcframe")
+    @test !contains(breakpoint_mutable_ir, "jl_gc_pool_alloc")
+    @test contains(get_llvm(MutableStruct, Tuple{}), "jl_gc_pool_alloc")
 end