diff --git a/Modules/Core/Common/include/itkObjectFactoryBase.h b/Modules/Core/Common/include/itkObjectFactoryBase.h
index 5f3f7863c56..3f4332f0f65 100644
--- a/Modules/Core/Common/include/itkObjectFactoryBase.h
+++ b/Modules/Core/Common/include/itkObjectFactoryBase.h
@@ -219,6 +219,25 @@ class ITKCommon_EXPORT ObjectFactoryBase : public Object
     CreateObjectFunctionBase::Pointer m_CreateObject;
   };
 
+  /** Registers the specified internal factory only once, even when `RegisterInternalFactoryOnce<TFactory>()` is called
+   * multiple times (possibly even by multiple threads) for the very same factory. */
+  template <typename TFactory>
+  static void
+  RegisterInternalFactoryOnce()
+  {
+    struct FactoryRegistration
+    {};
+
+    // Factory registration, made thread-safe by "magic statics" (as introduced with C++11).
+    static const FactoryRegistration staticFactoryRegistration = [] {
+      RegisterFactoryInternal(TFactory::New());
+      return FactoryRegistration{};
+    }();
+
+    (void)staticFactoryRegistration;
+  }
+
+
 protected:
   void
   PrintSelf(std::ostream & os, Indent indent) const override;
diff --git a/Modules/IO/BMP/src/itkBMPImageIOFactory.cxx b/Modules/IO/BMP/src/itkBMPImageIOFactory.cxx
index 97d7a768b60..d177b746bd7 100644
--- a/Modules/IO/BMP/src/itkBMPImageIOFactory.cxx
+++ b/Modules/IO/BMP/src/itkBMPImageIOFactory.cxx
@@ -43,17 +43,10 @@ BMPImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool BMPImageIOFactoryHasBeenRegistered;
-
 void ITKIOBMP_EXPORT
      BMPImageIOFactoryRegister__Private()
 {
-  if (!BMPImageIOFactoryHasBeenRegistered)
-  {
-    BMPImageIOFactoryHasBeenRegistered = true;
-    BMPImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<BMPImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/BioRad/src/itkBioRadImageIOFactory.cxx b/Modules/IO/BioRad/src/itkBioRadImageIOFactory.cxx
index 31325924a85..082a88e1bcc 100644
--- a/Modules/IO/BioRad/src/itkBioRadImageIOFactory.cxx
+++ b/Modules/IO/BioRad/src/itkBioRadImageIOFactory.cxx
@@ -53,17 +53,10 @@ BioRadImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool BioRadImageIOFactoryHasBeenRegistered;
-
 void ITKIOBioRad_EXPORT
      BioRadImageIOFactoryRegister__Private()
 {
-  if (!BioRadImageIOFactoryHasBeenRegistered)
-  {
-    BioRadImageIOFactoryHasBeenRegistered = true;
-    BioRadImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<BioRadImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/Bruker/src/itkBruker2dseqImageIOFactory.cxx b/Modules/IO/Bruker/src/itkBruker2dseqImageIOFactory.cxx
index 414dc4e8254..b35a9a0c7dc 100644
--- a/Modules/IO/Bruker/src/itkBruker2dseqImageIOFactory.cxx
+++ b/Modules/IO/Bruker/src/itkBruker2dseqImageIOFactory.cxx
@@ -56,16 +56,9 @@ Bruker2dseqImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool Bruker2dseqImageIOFactoryHasBeenRegistered;
-
 void ITKIOBruker_EXPORT
      Bruker2dseqImageIOFactoryRegister__Private()
 {
-  if (!Bruker2dseqImageIOFactoryHasBeenRegistered)
-  {
-    Bruker2dseqImageIOFactoryHasBeenRegistered = true;
-    Bruker2dseqImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<Bruker2dseqImageIOFactory>();
 }
 } // end namespace itk
diff --git a/Modules/IO/DCMTK/src/itkDCMTKImageIOFactory.cxx b/Modules/IO/DCMTK/src/itkDCMTKImageIOFactory.cxx
index 4154deb103d..be4edc94f71 100644
--- a/Modules/IO/DCMTK/src/itkDCMTKImageIOFactory.cxx
+++ b/Modules/IO/DCMTK/src/itkDCMTKImageIOFactory.cxx
@@ -43,17 +43,10 @@ DCMTKImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool DCMTKImageIOFactoryHasBeenRegistered;
-
 void ITKIODCMTK_EXPORT
      DCMTKImageIOFactoryRegister__Private()
 {
-  if (!DCMTKImageIOFactoryHasBeenRegistered)
-  {
-    DCMTKImageIOFactoryHasBeenRegistered = true;
-    DCMTKImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<DCMTKImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/GDCM/src/itkGDCMImageIOFactory.cxx b/Modules/IO/GDCM/src/itkGDCMImageIOFactory.cxx
index 5cff5eb502c..7164576cb24 100644
--- a/Modules/IO/GDCM/src/itkGDCMImageIOFactory.cxx
+++ b/Modules/IO/GDCM/src/itkGDCMImageIOFactory.cxx
@@ -43,17 +43,10 @@ GDCMImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool GDCMImageIOFactoryHasBeenRegistered;
-
 void ITKIOGDCM_EXPORT
      GDCMImageIOFactoryRegister__Private()
 {
-  if (!GDCMImageIOFactoryHasBeenRegistered)
-  {
-    GDCMImageIOFactoryHasBeenRegistered = true;
-    GDCMImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<GDCMImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/GE/src/itkGE4ImageIOFactory.cxx b/Modules/IO/GE/src/itkGE4ImageIOFactory.cxx
index d558805f220..db6fc06346b 100644
--- a/Modules/IO/GE/src/itkGE4ImageIOFactory.cxx
+++ b/Modules/IO/GE/src/itkGE4ImageIOFactory.cxx
@@ -47,17 +47,10 @@ GE4ImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool GE4ImageIOFactoryHasBeenRegistered;
-
 void ITKIOGE_EXPORT
      GE4ImageIOFactoryRegister__Private()
 {
-  if (!GE4ImageIOFactoryHasBeenRegistered)
-  {
-    GE4ImageIOFactoryHasBeenRegistered = true;
-    GE4ImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<GE4ImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/GE/src/itkGE5ImageIOFactory.cxx b/Modules/IO/GE/src/itkGE5ImageIOFactory.cxx
index 544a0a9c2ad..0b39ce04310 100644
--- a/Modules/IO/GE/src/itkGE5ImageIOFactory.cxx
+++ b/Modules/IO/GE/src/itkGE5ImageIOFactory.cxx
@@ -47,17 +47,10 @@ GE5ImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool GE5ImageIOFactoryHasBeenRegistered;
-
 void ITKIOGE_EXPORT
      GE5ImageIOFactoryRegister__Private()
 {
-  if (!GE5ImageIOFactoryHasBeenRegistered)
-  {
-    GE5ImageIOFactoryHasBeenRegistered = true;
-    GE5ImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<GE5ImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/GE/src/itkGEAdwImageIOFactory.cxx b/Modules/IO/GE/src/itkGEAdwImageIOFactory.cxx
index 0251f401bec..57680d54cd6 100644
--- a/Modules/IO/GE/src/itkGEAdwImageIOFactory.cxx
+++ b/Modules/IO/GE/src/itkGEAdwImageIOFactory.cxx
@@ -47,17 +47,10 @@ GEAdwImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool GEAdwImageIOFactoryHasBeenRegistered;
-
 void ITKIOGE_EXPORT
      GEAdwImageIOFactoryRegister__Private()
 {
-  if (!GEAdwImageIOFactoryHasBeenRegistered)
-  {
-    GEAdwImageIOFactoryHasBeenRegistered = true;
-    GEAdwImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<GEAdwImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/GIPL/src/itkGiplImageIOFactory.cxx b/Modules/IO/GIPL/src/itkGiplImageIOFactory.cxx
index 0d1cd84d55d..119f1b988bf 100644
--- a/Modules/IO/GIPL/src/itkGiplImageIOFactory.cxx
+++ b/Modules/IO/GIPL/src/itkGiplImageIOFactory.cxx
@@ -43,17 +43,10 @@ GiplImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool GiplImageIOFactoryHasBeenRegistered;
-
 void ITKIOGIPL_EXPORT
      GiplImageIOFactoryRegister__Private()
 {
-  if (!GiplImageIOFactoryHasBeenRegistered)
-  {
-    GiplImageIOFactoryHasBeenRegistered = true;
-    GiplImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<GiplImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/HDF5/src/itkHDF5ImageIOFactory.cxx b/Modules/IO/HDF5/src/itkHDF5ImageIOFactory.cxx
index 24e982bb90e..e5d159a2a92 100644
--- a/Modules/IO/HDF5/src/itkHDF5ImageIOFactory.cxx
+++ b/Modules/IO/HDF5/src/itkHDF5ImageIOFactory.cxx
@@ -47,17 +47,10 @@ HDF5ImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool HDF5ImageIOFactoryHasBeenRegistered;
-
 void ITKIOHDF5_EXPORT
      HDF5ImageIOFactoryRegister__Private()
 {
-  if (!HDF5ImageIOFactoryHasBeenRegistered)
-  {
-    HDF5ImageIOFactoryHasBeenRegistered = true;
-    HDF5ImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<HDF5ImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/JPEG/src/itkJPEGImageIOFactory.cxx b/Modules/IO/JPEG/src/itkJPEGImageIOFactory.cxx
index 49744374af7..f2472aecf34 100644
--- a/Modules/IO/JPEG/src/itkJPEGImageIOFactory.cxx
+++ b/Modules/IO/JPEG/src/itkJPEGImageIOFactory.cxx
@@ -43,17 +43,10 @@ JPEGImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool JPEGImageIOFactoryHasBeenRegistered;
-
 void ITKIOJPEG_EXPORT
      JPEGImageIOFactoryRegister__Private()
 {
-  if (!JPEGImageIOFactoryHasBeenRegistered)
-  {
-    JPEGImageIOFactoryHasBeenRegistered = true;
-    JPEGImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<JPEGImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/JPEG2000/src/itkJPEG2000ImageIOFactory.cxx b/Modules/IO/JPEG2000/src/itkJPEG2000ImageIOFactory.cxx
index 7c1ecc40b73..ff2477fb6d4 100644
--- a/Modules/IO/JPEG2000/src/itkJPEG2000ImageIOFactory.cxx
+++ b/Modules/IO/JPEG2000/src/itkJPEG2000ImageIOFactory.cxx
@@ -44,17 +44,10 @@ JPEG2000ImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool JPEG2000ImageIOFactoryHasBeenRegistered;
-
 void ITKIOJPEG2000_EXPORT
      JPEG2000ImageIOFactoryRegister__Private()
 {
-  if (!JPEG2000ImageIOFactoryHasBeenRegistered)
-  {
-    JPEG2000ImageIOFactoryHasBeenRegistered = true;
-    JPEG2000ImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<JPEG2000ImageIOFactory>();
 }
 
 
diff --git a/Modules/IO/LSM/src/itkLSMImageIOFactory.cxx b/Modules/IO/LSM/src/itkLSMImageIOFactory.cxx
index 02d539ed48b..bba9dff4442 100644
--- a/Modules/IO/LSM/src/itkLSMImageIOFactory.cxx
+++ b/Modules/IO/LSM/src/itkLSMImageIOFactory.cxx
@@ -53,17 +53,10 @@ LSMImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool LSMImageIOFactoryHasBeenRegistered;
-
 void ITKIOLSM_EXPORT
      LSMImageIOFactoryRegister__Private()
 {
-  if (!LSMImageIOFactoryHasBeenRegistered)
-  {
-    LSMImageIOFactoryHasBeenRegistered = true;
-    LSMImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<LSMImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MINC/src/itkMINCImageIOFactory.cxx b/Modules/IO/MINC/src/itkMINCImageIOFactory.cxx
index 2870ec81756..c5dc19e6c7a 100644
--- a/Modules/IO/MINC/src/itkMINCImageIOFactory.cxx
+++ b/Modules/IO/MINC/src/itkMINCImageIOFactory.cxx
@@ -43,17 +43,10 @@ MINCImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool MINCImageIOFactoryHasBeenRegistered;
-
 void ITKIOMINC_EXPORT
      MINCImageIOFactoryRegister__Private()
 {
-  if (!MINCImageIOFactoryHasBeenRegistered)
-  {
-    MINCImageIOFactoryHasBeenRegistered = true;
-    MINCImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<MINCImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MRC/src/itkMRCImageIOFactory.cxx b/Modules/IO/MRC/src/itkMRCImageIOFactory.cxx
index 80ba9f1814a..980b1ead426 100644
--- a/Modules/IO/MRC/src/itkMRCImageIOFactory.cxx
+++ b/Modules/IO/MRC/src/itkMRCImageIOFactory.cxx
@@ -53,17 +53,10 @@ MRCImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool MRCImageIOFactoryHasBeenRegistered;
-
 void ITKIOMRC_EXPORT
      MRCImageIOFactoryRegister__Private()
 {
-  if (!MRCImageIOFactoryHasBeenRegistered)
-  {
-    MRCImageIOFactoryHasBeenRegistered = true;
-    MRCImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<MRCImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshBYU/src/itkBYUMeshIOFactory.cxx b/Modules/IO/MeshBYU/src/itkBYUMeshIOFactory.cxx
index a7b0d5d8019..bc4063ab18c 100644
--- a/Modules/IO/MeshBYU/src/itkBYUMeshIOFactory.cxx
+++ b/Modules/IO/MeshBYU/src/itkBYUMeshIOFactory.cxx
@@ -52,16 +52,10 @@ BYUMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool BYUMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshBYU_EXPORT
      BYUMeshIOFactoryRegister__Private()
 {
-  if (!BYUMeshIOFactoryHasBeenRegistered)
-  {
-    BYUMeshIOFactoryHasBeenRegistered = true;
-    BYUMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<BYUMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshFreeSurfer/src/itkFreeSurferAsciiMeshIOFactory.cxx b/Modules/IO/MeshFreeSurfer/src/itkFreeSurferAsciiMeshIOFactory.cxx
index 9712e45bb43..38828daae13 100644
--- a/Modules/IO/MeshFreeSurfer/src/itkFreeSurferAsciiMeshIOFactory.cxx
+++ b/Modules/IO/MeshFreeSurfer/src/itkFreeSurferAsciiMeshIOFactory.cxx
@@ -52,16 +52,10 @@ FreeSurferAsciiMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool FreeSurferAsciiMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshFreeSurfer_EXPORT
      FreeSurferAsciiMeshIOFactoryRegister__Private()
 {
-  if (!FreeSurferAsciiMeshIOFactoryHasBeenRegistered)
-  {
-    FreeSurferAsciiMeshIOFactoryHasBeenRegistered = true;
-    FreeSurferAsciiMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<FreeSurferAsciiMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshFreeSurfer/src/itkFreeSurferBinaryMeshIOFactory.cxx b/Modules/IO/MeshFreeSurfer/src/itkFreeSurferBinaryMeshIOFactory.cxx
index 6348210eab1..67850f2e15a 100644
--- a/Modules/IO/MeshFreeSurfer/src/itkFreeSurferBinaryMeshIOFactory.cxx
+++ b/Modules/IO/MeshFreeSurfer/src/itkFreeSurferBinaryMeshIOFactory.cxx
@@ -52,16 +52,10 @@ FreeSurferBinaryMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool FreeSurferBinaryMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshFreeSurfer_EXPORT
      FreeSurferBinaryMeshIOFactoryRegister__Private()
 {
-  if (!FreeSurferBinaryMeshIOFactoryHasBeenRegistered)
-  {
-    FreeSurferBinaryMeshIOFactoryHasBeenRegistered = true;
-    FreeSurferBinaryMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<FreeSurferBinaryMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshGifti/src/itkGiftiMeshIOFactory.cxx b/Modules/IO/MeshGifti/src/itkGiftiMeshIOFactory.cxx
index 0064a835456..533a719efc1 100644
--- a/Modules/IO/MeshGifti/src/itkGiftiMeshIOFactory.cxx
+++ b/Modules/IO/MeshGifti/src/itkGiftiMeshIOFactory.cxx
@@ -49,16 +49,10 @@ GiftiMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool GiftiMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshGifti_EXPORT
      GiftiMeshIOFactoryRegister__Private()
 {
-  if (!GiftiMeshIOFactoryHasBeenRegistered)
-  {
-    GiftiMeshIOFactoryHasBeenRegistered = true;
-    GiftiMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<GiftiMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshOBJ/src/itkOBJMeshIOFactory.cxx b/Modules/IO/MeshOBJ/src/itkOBJMeshIOFactory.cxx
index e2d1d4ff1f5..9fcf0e147bf 100644
--- a/Modules/IO/MeshOBJ/src/itkOBJMeshIOFactory.cxx
+++ b/Modules/IO/MeshOBJ/src/itkOBJMeshIOFactory.cxx
@@ -48,16 +48,10 @@ OBJMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool OBJMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshOBJ_EXPORT
      OBJMeshIOFactoryRegister__Private()
 {
-  if (!OBJMeshIOFactoryHasBeenRegistered)
-  {
-    OBJMeshIOFactoryHasBeenRegistered = true;
-    OBJMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<OBJMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshOFF/src/itkOFFMeshIOFactory.cxx b/Modules/IO/MeshOFF/src/itkOFFMeshIOFactory.cxx
index 9bf5e167cda..8c6cc7093e8 100644
--- a/Modules/IO/MeshOFF/src/itkOFFMeshIOFactory.cxx
+++ b/Modules/IO/MeshOFF/src/itkOFFMeshIOFactory.cxx
@@ -48,16 +48,10 @@ OFFMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool OFFMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshOFF_EXPORT
      OFFMeshIOFactoryRegister__Private()
 {
-  if (!OFFMeshIOFactoryHasBeenRegistered)
-  {
-    OFFMeshIOFactoryHasBeenRegistered = true;
-    OFFMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<OFFMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/MeshVTK/src/itkVTKPolyDataMeshIOFactory.cxx b/Modules/IO/MeshVTK/src/itkVTKPolyDataMeshIOFactory.cxx
index 335d41deb9b..cd9a98d2403 100644
--- a/Modules/IO/MeshVTK/src/itkVTKPolyDataMeshIOFactory.cxx
+++ b/Modules/IO/MeshVTK/src/itkVTKPolyDataMeshIOFactory.cxx
@@ -54,16 +54,10 @@ VTKPolyDataMeshIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool VTKPolyDataMeshIOFactoryHasBeenRegistered;
-
 void ITKIOMeshVTK_EXPORT
      VTKPolyDataMeshIOFactoryRegister__Private()
 {
-  if (!VTKPolyDataMeshIOFactoryHasBeenRegistered)
-  {
-    VTKPolyDataMeshIOFactoryHasBeenRegistered = true;
-    VTKPolyDataMeshIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<VTKPolyDataMeshIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/Meta/src/itkMetaImageIOFactory.cxx b/Modules/IO/Meta/src/itkMetaImageIOFactory.cxx
index b636e34f82a..ae53a1385fa 100644
--- a/Modules/IO/Meta/src/itkMetaImageIOFactory.cxx
+++ b/Modules/IO/Meta/src/itkMetaImageIOFactory.cxx
@@ -43,17 +43,10 @@ MetaImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool MetaImageIOFactoryHasBeenRegistered;
-
 void ITKIOMeta_EXPORT
      MetaImageIOFactoryRegister__Private()
 {
-  if (!MetaImageIOFactoryHasBeenRegistered)
-  {
-    MetaImageIOFactoryHasBeenRegistered = true;
-    MetaImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<MetaImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/NIFTI/src/itkNiftiImageIOFactory.cxx b/Modules/IO/NIFTI/src/itkNiftiImageIOFactory.cxx
index be1ee1a8a51..c7d3dbba1b4 100644
--- a/Modules/IO/NIFTI/src/itkNiftiImageIOFactory.cxx
+++ b/Modules/IO/NIFTI/src/itkNiftiImageIOFactory.cxx
@@ -47,17 +47,10 @@ NiftiImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool NiftiImageIOFactoryHasBeenRegistered;
-
 void ITKIONIFTI_EXPORT
      NiftiImageIOFactoryRegister__Private()
 {
-  if (!NiftiImageIOFactoryHasBeenRegistered)
-  {
-    NiftiImageIOFactoryHasBeenRegistered = true;
-    NiftiImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<NiftiImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/NRRD/src/itkNrrdImageIOFactory.cxx b/Modules/IO/NRRD/src/itkNrrdImageIOFactory.cxx
index 89976a3c82f..cb147f34d2c 100644
--- a/Modules/IO/NRRD/src/itkNrrdImageIOFactory.cxx
+++ b/Modules/IO/NRRD/src/itkNrrdImageIOFactory.cxx
@@ -43,17 +43,10 @@ NrrdImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool NrrdImageIOFactoryHasBeenRegistered;
-
 void ITKIONRRD_EXPORT
      NrrdImageIOFactoryRegister__Private()
 {
-  if (!NrrdImageIOFactoryHasBeenRegistered)
-  {
-    NrrdImageIOFactoryHasBeenRegistered = true;
-    NrrdImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<NrrdImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/PNG/src/itkPNGImageIOFactory.cxx b/Modules/IO/PNG/src/itkPNGImageIOFactory.cxx
index 061ec9b99f2..8b22f1f9895 100644
--- a/Modules/IO/PNG/src/itkPNGImageIOFactory.cxx
+++ b/Modules/IO/PNG/src/itkPNGImageIOFactory.cxx
@@ -43,17 +43,10 @@ PNGImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool PNGImageIOFactoryHasBeenRegistered;
-
 void ITKIOPNG_EXPORT
      PNGImageIOFactoryRegister__Private()
 {
-  if (!PNGImageIOFactoryHasBeenRegistered)
-  {
-    PNGImageIOFactoryHasBeenRegistered = true;
-    PNGImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<PNGImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/PhilipsREC/src/itkPhilipsRECImageIOFactory.cxx b/Modules/IO/PhilipsREC/src/itkPhilipsRECImageIOFactory.cxx
index aca38b8562b..ecd3719d32b 100644
--- a/Modules/IO/PhilipsREC/src/itkPhilipsRECImageIOFactory.cxx
+++ b/Modules/IO/PhilipsREC/src/itkPhilipsRECImageIOFactory.cxx
@@ -58,17 +58,10 @@ PhilipsRECImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool PhilipsRECImageIOFactoryHasBeenRegistered;
-
 void ITKIOPhilipsREC_EXPORT
      PhilipsRECImageIOFactoryRegister__Private()
 {
-  if (!PhilipsRECImageIOFactoryHasBeenRegistered)
-  {
-    PhilipsRECImageIOFactoryHasBeenRegistered = true;
-    PhilipsRECImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<PhilipsRECImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/Siemens/src/itkSiemensVisionImageIOFactory.cxx b/Modules/IO/Siemens/src/itkSiemensVisionImageIOFactory.cxx
index 76c69003693..591a54eab0e 100644
--- a/Modules/IO/Siemens/src/itkSiemensVisionImageIOFactory.cxx
+++ b/Modules/IO/Siemens/src/itkSiemensVisionImageIOFactory.cxx
@@ -50,17 +50,10 @@ SiemensVisionImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool SiemensVisionImageIOFactoryHasBeenRegistered;
-
 void ITKIOSiemens_EXPORT
      SiemensVisionImageIOFactoryRegister__Private()
 {
-  if (!SiemensVisionImageIOFactoryHasBeenRegistered)
-  {
-    SiemensVisionImageIOFactoryHasBeenRegistered = true;
-    SiemensVisionImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<SiemensVisionImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/Stimulate/src/itkStimulateImageIOFactory.cxx b/Modules/IO/Stimulate/src/itkStimulateImageIOFactory.cxx
index 70118ebcda5..2140c8c3bbe 100644
--- a/Modules/IO/Stimulate/src/itkStimulateImageIOFactory.cxx
+++ b/Modules/IO/Stimulate/src/itkStimulateImageIOFactory.cxx
@@ -53,17 +53,10 @@ StimulateImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool StimulateImageIOFactoryHasBeenRegistered;
-
 void ITKIOStimulate_EXPORT
      StimulateImageIOFactoryRegister__Private()
 {
-  if (!StimulateImageIOFactoryHasBeenRegistered)
-  {
-    StimulateImageIOFactoryHasBeenRegistered = true;
-    StimulateImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<StimulateImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/TIFF/src/itkTIFFImageIOFactory.cxx b/Modules/IO/TIFF/src/itkTIFFImageIOFactory.cxx
index 83f759e18aa..7d9fa322501 100644
--- a/Modules/IO/TIFF/src/itkTIFFImageIOFactory.cxx
+++ b/Modules/IO/TIFF/src/itkTIFFImageIOFactory.cxx
@@ -43,17 +43,10 @@ TIFFImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool TIFFImageIOFactoryHasBeenRegistered;
-
 void ITKIOTIFF_EXPORT
      TIFFImageIOFactoryRegister__Private()
 {
-  if (!TIFFImageIOFactoryHasBeenRegistered)
-  {
-    TIFFImageIOFactoryHasBeenRegistered = true;
-    TIFFImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<TIFFImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/IO/TransformHDF5/src/itkHDF5TransformIOFactory.cxx b/Modules/IO/TransformHDF5/src/itkHDF5TransformIOFactory.cxx
index 45eead1d66f..68e9d236b21 100644
--- a/Modules/IO/TransformHDF5/src/itkHDF5TransformIOFactory.cxx
+++ b/Modules/IO/TransformHDF5/src/itkHDF5TransformIOFactory.cxx
@@ -58,15 +58,9 @@ HDF5TransformIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool HDF5TransformIOFactoryHasBeenRegistered;
-
 void ITKIOTransformHDF5_EXPORT
      HDF5TransformIOFactoryRegister__Private()
 {
-  if (!HDF5TransformIOFactoryHasBeenRegistered)
-  {
-    HDF5TransformIOFactoryHasBeenRegistered = true;
-    HDF5TransformIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<HDF5TransformIOFactory>();
 }
 } // end namespace itk
diff --git a/Modules/IO/TransformInsightLegacy/src/itkTxtTransformIOFactory.cxx b/Modules/IO/TransformInsightLegacy/src/itkTxtTransformIOFactory.cxx
index 50e5e5bbbb2..55a630d95ba 100644
--- a/Modules/IO/TransformInsightLegacy/src/itkTxtTransformIOFactory.cxx
+++ b/Modules/IO/TransformInsightLegacy/src/itkTxtTransformIOFactory.cxx
@@ -57,15 +57,9 @@ TxtTransformIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool TxtTransformIOFactoryHasBeenRegistered;
-
 void ITKIOTransformInsightLegacy_EXPORT
      TxtTransformIOFactoryRegister__Private()
 {
-  if (!TxtTransformIOFactoryHasBeenRegistered)
-  {
-    TxtTransformIOFactoryHasBeenRegistered = true;
-    TxtTransformIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<TxtTransformIOFactory>();
 }
 } // end namespace itk
diff --git a/Modules/IO/TransformMINC/src/itkMINCTransformIOFactory.cxx b/Modules/IO/TransformMINC/src/itkMINCTransformIOFactory.cxx
index dea21d233e2..a0b3817bebc 100644
--- a/Modules/IO/TransformMINC/src/itkMINCTransformIOFactory.cxx
+++ b/Modules/IO/TransformMINC/src/itkMINCTransformIOFactory.cxx
@@ -60,19 +60,13 @@ MINCTransformIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool MINCTransformIOFactoryHasBeenRegistered;
-
 void ITKIOTransformMINC_EXPORT
      MINCTransformIOFactoryRegister__Private()
 {
-  if (!MINCTransformIOFactoryHasBeenRegistered)
-  {
-    MINCTransformIOFactoryHasBeenRegistered = true;
-    MINCTransformIOFactory::RegisterOneFactory();
+  ObjectFactoryBase::RegisterInternalFactoryOnce<MINCTransformIOFactory>();
 
-    // TransformFactory< DisplacementFieldTransform<double,3> >::RegisterTransform ();
-    // register additional transform type
-  }
+  // TransformFactory< DisplacementFieldTransform<double,3> >::RegisterTransform ();
+  // register additional transform type
 }
 
 } // end namespace itk
diff --git a/Modules/IO/TransformMatlab/src/itkMatlabTransformIOFactory.cxx b/Modules/IO/TransformMatlab/src/itkMatlabTransformIOFactory.cxx
index f632b2572c5..209574d5844 100644
--- a/Modules/IO/TransformMatlab/src/itkMatlabTransformIOFactory.cxx
+++ b/Modules/IO/TransformMatlab/src/itkMatlabTransformIOFactory.cxx
@@ -57,15 +57,9 @@ MatlabTransformIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-static bool MatlabTransformIOFactoryHasBeenRegistered;
-
 void ITKIOTransformMatlab_EXPORT
      MatlabTransformIOFactoryRegister__Private()
 {
-  if (!MatlabTransformIOFactoryHasBeenRegistered)
-  {
-    MatlabTransformIOFactoryHasBeenRegistered = true;
-    MatlabTransformIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<MatlabTransformIOFactory>();
 }
 } // end namespace itk
diff --git a/Modules/IO/VTK/src/itkVTKImageIOFactory.cxx b/Modules/IO/VTK/src/itkVTKImageIOFactory.cxx
index 2c77d6ae4d3..3747d8860de 100644
--- a/Modules/IO/VTK/src/itkVTKImageIOFactory.cxx
+++ b/Modules/IO/VTK/src/itkVTKImageIOFactory.cxx
@@ -53,17 +53,10 @@ VTKImageIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool VTKImageIOFactoryHasBeenRegistered;
-
 void ITKIOVTK_EXPORT
      VTKImageIOFactoryRegister__Private()
 {
-  if (!VTKImageIOFactoryHasBeenRegistered)
-  {
-    VTKImageIOFactoryHasBeenRegistered = true;
-    VTKImageIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<VTKImageIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/Video/BridgeOpenCV/src/itkOpenCVVideoIOFactory.cxx b/Modules/Video/BridgeOpenCV/src/itkOpenCVVideoIOFactory.cxx
index 0a35ed5d50f..8f7714459cd 100644
--- a/Modules/Video/BridgeOpenCV/src/itkOpenCVVideoIOFactory.cxx
+++ b/Modules/Video/BridgeOpenCV/src/itkOpenCVVideoIOFactory.cxx
@@ -43,17 +43,10 @@ OpenCVVideoIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool OpenCVVideoIOFactoryHasBeenRegistered;
-
 void
 OpenCVVideoIOFactoryRegister__Private()
 {
-  if (!OpenCVVideoIOFactoryHasBeenRegistered)
-  {
-    OpenCVVideoIOFactoryHasBeenRegistered = true;
-    OpenCVVideoIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<OpenCVVideoIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/Video/BridgeVXL/src/itkVXLVideoIOFactory.cxx b/Modules/Video/BridgeVXL/src/itkVXLVideoIOFactory.cxx
index d932b412719..ff23e863083 100644
--- a/Modules/Video/BridgeVXL/src/itkVXLVideoIOFactory.cxx
+++ b/Modules/Video/BridgeVXL/src/itkVXLVideoIOFactory.cxx
@@ -42,17 +42,10 @@ VXLVideoIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool VXLVideoIOFactoryHasBeenRegistered;
-
 void
 VXLVideoIOFactoryRegister__Private()
 {
-  if (!VXLVideoIOFactoryHasBeenRegistered)
-  {
-    VXLVideoIOFactoryHasBeenRegistered = true;
-    VXLVideoIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<VXLVideoIOFactory>();
 }
 
 } // end namespace itk
diff --git a/Modules/Video/IO/src/itkFileListVideoIOFactory.cxx b/Modules/Video/IO/src/itkFileListVideoIOFactory.cxx
index 5207ac3b67f..a27d4a017a6 100644
--- a/Modules/Video/IO/src/itkFileListVideoIOFactory.cxx
+++ b/Modules/Video/IO/src/itkFileListVideoIOFactory.cxx
@@ -43,17 +43,10 @@ FileListVideoIOFactory::GetDescription() const
 
 // Undocumented API used to register during static initialization.
 // DO NOT CALL DIRECTLY.
-
-static bool FileListVideoIOFactoryHasBeenRegistered;
-
 void
 FileListVideoIOFactoryRegister__Private()
 {
-  if (!FileListVideoIOFactoryHasBeenRegistered)
-  {
-    FileListVideoIOFactoryHasBeenRegistered = true;
-    FileListVideoIOFactory::RegisterOneFactory();
-  }
+  ObjectFactoryBase::RegisterInternalFactoryOnce<FileListVideoIOFactory>();
 }
 
 } // end namespace itk