diff --git a/Modules/Core/Common/include/itkImageRegion.h b/Modules/Core/Common/include/itkImageRegion.h
index 8045eb42fc9..2efad05a220 100644
--- a/Modules/Core/Common/include/itkImageRegion.h
+++ b/Modules/Core/Common/include/itkImageRegion.h
@@ -34,6 +34,15 @@
 #include "itkContinuousIndex.h"
 #include "itkMath.h"
 
+// Macro added to each `ImageRegion` member function that overrides a virtual member function of `Region`. In the
+// future, `ImageRegion` will no longer inherit from `Region`, so then those `ImageRegion` member functions will no
+// longer override.
+#ifdef ITK_FUTURE_LEGACY_REMOVE
+#  define itkRegionOverrideMacro // nothing (in the future)
+#else
+#  define itkRegionOverrideMacro override
+#endif
+
 namespace itk
 {
 // Forward declaration of ImageBase so it can be declared a friend
@@ -66,15 +75,26 @@ class ITK_TEMPLATE_EXPORT ImageBase;
  * \endsphinx
  */
 template <unsigned int VImageDimension>
-class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
+class ITK_TEMPLATE_EXPORT ImageRegion final
+#ifndef ITK_FUTURE_LEGACY_REMOVE
+  // This inheritance is to be removed in the future.
+  : public Region
+#endif
 {
 public:
   /** Standard class type aliases. */
   using Self = ImageRegion;
+
+#ifndef ITK_FUTURE_LEGACY_REMOVE
   using Superclass = Region;
+#endif
 
   /** Standard part of all itk objects. */
-  itkTypeMacro(ImageRegion, Region);
+  const char *
+  GetNameOfClass() const itkRegionOverrideMacro
+  {
+    return "ImageRegion";
+  }
 
   /** Dimension of the image available at compile time. */
   static constexpr unsigned int ImageDimension = VImageDimension;
@@ -106,12 +126,16 @@ class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
   using SliceRegion = ImageRegion<Self::SliceDimension>;
 
   /** Return the region type. Images are described with structured regions. */
-  Superclass::RegionEnum
-  GetRegionType() const override
+  Region::RegionEnum
+  GetRegionType() const itkRegionOverrideMacro
   {
-    return Superclass::RegionEnum::ITK_STRUCTURED_REGION;
+    return Region::RegionEnum::ITK_STRUCTURED_REGION;
   }
 
+  /** Print the region. */
+  void
+  Print(std::ostream & os, Indent indent = 0) const itkRegionOverrideMacro;
+
   /** Constructor. ImageRegion is a lightweight object that is not reference
    * counted, so the constructor is public. Its two data members are filled
    * with zeros (using C++11 default member initializers). */
@@ -119,7 +143,7 @@ class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
 
   /** Destructor. ImageRegion is a lightweight object that is not reference
    * counted, so the destructor is public. */
-  ~ImageRegion() override = default;
+  ~ImageRegion() itkRegionOverrideMacro = default;
 
   /** Copy constructor. ImageRegion is a lightweight object that is not
    * reference counted, so the copy constructor is public. */
@@ -339,7 +363,7 @@ class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
    * instead) but used in the hierarchical print process to combine the
    * output of several classes.  */
   void
-  PrintSelf(std::ostream & os, Indent indent) const override;
+  PrintSelf(std::ostream & os, Indent indent) const itkRegionOverrideMacro;
 
 private:
   IndexType m_Index = { { 0 } };
@@ -354,6 +378,8 @@ std::ostream &
 operator<<(std::ostream & os, const ImageRegion<VImageDimension> & region);
 } // end namespace itk
 
+#undef itkRegionOverrideMacro
+
 #ifndef ITK_MANUAL_INSTANTIATION
 #  include "itkImageRegion.hxx"
 #endif
diff --git a/Modules/Core/Common/include/itkImageRegion.hxx b/Modules/Core/Common/include/itkImageRegion.hxx
index 6385cd615e2..fd8d9838c25 100644
--- a/Modules/Core/Common/include/itkImageRegion.hxx
+++ b/Modules/Core/Common/include/itkImageRegion.hxx
@@ -84,10 +84,16 @@ ImageRegion<VImageDimension>::GetNumberOfPixels() const -> SizeValueType
 
 template <unsigned int VImageDimension>
 void
-ImageRegion<VImageDimension>::PrintSelf(std::ostream & os, Indent indent) const
+ImageRegion<VImageDimension>::Print(std::ostream & os, Indent indent) const
 {
-  Superclass::PrintSelf(os, indent);
+  os << indent << this->GetNameOfClass() << " (" << this << ")\n";
+  this->PrintSelf(os, indent.GetNextIndent());
+}
 
+template <unsigned int VImageDimension>
+void
+ImageRegion<VImageDimension>::PrintSelf(std::ostream & os, Indent indent) const
+{
   os << indent << "Dimension: " << this->GetImageDimension() << std::endl;
   os << indent << "Index: " << m_Index << std::endl;
   os << indent << "Size: " << m_Size << std::endl;
diff --git a/Modules/Core/Common/test/itkImageRegionGTest.cxx b/Modules/Core/Common/test/itkImageRegionGTest.cxx
index be25e72d864..7892aa1ad9a 100644
--- a/Modules/Core/Common/test/itkImageRegionGTest.cxx
+++ b/Modules/Core/Common/test/itkImageRegionGTest.cxx
@@ -24,6 +24,28 @@
 #include <type_traits> // For remove_const_t and remove_reference_t.
 
 
+namespace
+{
+template <unsigned int VDimension>
+constexpr bool
+CheckTrivialCopyabilityOfImageRegion()
+{
+  constexpr bool isImageRegionTriviallyCopyable{ std::is_trivially_copyable_v<itk::ImageRegion<VDimension>> };
+
+#ifdef ITK_FUTURE_LEGACY_REMOVE
+  static_assert(isImageRegionTriviallyCopyable, "In the future, ImageRegion<VDimension> should be trivially copyable.");
+  return isImageRegionTriviallyCopyable;
+#else
+  static_assert(!isImageRegionTriviallyCopyable, "ImageRegion<VDimension> should *not* be trivially copyable.");
+  return !isImageRegionTriviallyCopyable;
+#endif
+}
+} // namespace
+
+static_assert(CheckTrivialCopyabilityOfImageRegion<2>() && CheckTrivialCopyabilityOfImageRegion<3>(),
+              "ImageRegion<VDimension> should be trivially copyable when legacy support is removed.");
+
+
 // Tests that a zero-sized region is not considered to be inside of another region.
 TEST(ImageRegion, ZeroSizedRegionIsNotInside)
 {