diff --git a/Modules/Core/Common/include/itkImageRegion.h b/Modules/Core/Common/include/itkImageRegion.h
index 8045eb42fc91..335fffa68db3 100644
--- a/Modules/Core/Common/include/itkImageRegion.h
+++ b/Modules/Core/Common/include/itkImageRegion.h
@@ -66,15 +66,18 @@ class ITK_TEMPLATE_EXPORT ImageBase;
  * \endsphinx
  */
 template <unsigned int VImageDimension>
-class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
+class ITK_TEMPLATE_EXPORT ImageRegion final
 {
 public:
   /** Standard class type aliases. */
   using Self = ImageRegion;
-  using Superclass = Region;
 
-  /** Standard part of all itk objects. */
-  itkTypeMacro(ImageRegion, Region);
+  /** Standard part of all itk objects, but non-virtual. */
+  const char *
+  GetNameOfClass() const
+  {
+    return "ImageRegion";
+  }
 
   /** Dimension of the image available at compile time. */
   static constexpr unsigned int ImageDimension = VImageDimension;
@@ -106,12 +109,16 @@ class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
   using SliceRegion = ImageRegion<Self::SliceDimension>;
 
   /** Return the region type. Images are described with structured regions. */
-  Superclass::RegionEnum
-  GetRegionType() const override
+  Region::RegionEnum
+  GetRegionType() const
   {
-    return Superclass::RegionEnum::ITK_STRUCTURED_REGION;
+    return Region::RegionEnum::ITK_STRUCTURED_REGION;
   }
 
+  /** Print the region. */
+  void
+  Print(std::ostream & os, Indent indent = 0) const;
+
   /** Constructor. ImageRegion is a lightweight object that is not reference
    * counted, so the constructor is public. Its two data members are filled
    * with zeros (using C++11 default member initializers). */
@@ -119,7 +126,7 @@ class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
 
   /** Destructor. ImageRegion is a lightweight object that is not reference
    * counted, so the destructor is public. */
-  ~ImageRegion() override = default;
+  ~ImageRegion() = default;
 
   /** Copy constructor. ImageRegion is a lightweight object that is not
    * reference counted, so the copy constructor is public. */
@@ -339,7 +346,7 @@ class ITK_TEMPLATE_EXPORT ImageRegion final : public Region
    * instead) but used in the hierarchical print process to combine the
    * output of several classes.  */
   void
-  PrintSelf(std::ostream & os, Indent indent) const override;
+  PrintSelf(std::ostream & os, Indent indent) const;
 
 private:
   IndexType m_Index = { { 0 } };
diff --git a/Modules/Core/Common/include/itkImageRegion.hxx b/Modules/Core/Common/include/itkImageRegion.hxx
index 6385cd615e24..fd8d9838c25e 100644
--- a/Modules/Core/Common/include/itkImageRegion.hxx
+++ b/Modules/Core/Common/include/itkImageRegion.hxx
@@ -84,10 +84,16 @@ ImageRegion<VImageDimension>::GetNumberOfPixels() const -> SizeValueType
 
 template <unsigned int VImageDimension>
 void
-ImageRegion<VImageDimension>::PrintSelf(std::ostream & os, Indent indent) const
+ImageRegion<VImageDimension>::Print(std::ostream & os, Indent indent) const
 {
-  Superclass::PrintSelf(os, indent);
+  os << indent << this->GetNameOfClass() << " (" << this << ")\n";
+  this->PrintSelf(os, indent.GetNextIndent());
+}
 
+template <unsigned int VImageDimension>
+void
+ImageRegion<VImageDimension>::PrintSelf(std::ostream & os, Indent indent) const
+{
   os << indent << "Dimension: " << this->GetImageDimension() << std::endl;
   os << indent << "Index: " << m_Index << std::endl;
   os << indent << "Size: " << m_Size << std::endl;
diff --git a/Modules/Core/Common/test/itkImageRegionTest.cxx b/Modules/Core/Common/test/itkImageRegionTest.cxx
index c75b1f748b90..7b13008c9885 100644
--- a/Modules/Core/Common/test/itkImageRegionTest.cxx
+++ b/Modules/Core/Common/test/itkImageRegionTest.cxx
@@ -17,9 +17,15 @@
  *=========================================================================*/
 
 #include <iostream>
+#include <type_traits> // For is_trivially_copyable_v.
 #include "itkImageRegion.h"
 #include "itkFloatingPointExceptions.h"
 
+
+static_assert(std::is_trivially_copyable_v<itk::ImageRegion<2>> && std::is_trivially_copyable_v<itk::ImageRegion<3>>,
+              "ImageRegion<VImageDimension> should be trivially copyable.");
+
+
 int
 itkImageRegionTest(int, char *[])
 {