diff --git a/src/docker/itk-wasm-base/build.sh b/src/docker/itk-wasm-base/build.sh
index 3236948e3..31b3fcedc 100755
--- a/src/docker/itk-wasm-base/build.sh
+++ b/src/docker/itk-wasm-base/build.sh
@@ -26,7 +26,7 @@ done
 set -- "${newparams[@]}"  # overwrites the original positional params
 
 wasi_ld_flags="-flto -lwasi-emulated-process-clocks -lwasi-emulated-signal -lc-printscan-long-double"
-wasi_c_flags="-flto -D_WASI_EMULATED_PROCESS_CLOCKS -D_WASI_EMULATED_SIGNAL"
+wasi_c_flags="-flto -msimd128 -D_WASI_EMULATED_PROCESS_CLOCKS -D_WASI_EMULATED_SIGNAL"
 
 emscripten_debug_ld_flags="-fno-lto -s ALLOW_MEMORY_GROWTH=1"
 emscripten_debug_c_flags="-fno-lto -Wno-warn-absolute-paths"