diff --git a/packages/compare-images/python/itkwasm-compare-images/pyproject.toml b/packages/compare-images/python/itkwasm-compare-images/pyproject.toml
index e1efc21fd..b5cd11b13 100644
--- a/packages/compare-images/python/itkwasm-compare-images/pyproject.toml
+++ b/packages/compare-images/python/itkwasm-compare-images/pyproject.toml
@@ -6,7 +6,8 @@ build-backend = "hatchling.build"
 name = "itkwasm-compare-images"
 readme = "README.md"
 license = "Apache-2.0"
-dynamic = ["version", "description"]
+dynamic = ["version"]
+description = "Compare images with a tolerance for regression testing."
 classifiers = [
   "License :: OSI Approved :: Apache Software License",
   "Programming Language :: Python",
diff --git a/packages/compress-stringify/python/itkwasm-compress-stringify/pyproject.toml b/packages/compress-stringify/python/itkwasm-compress-stringify/pyproject.toml
index aa1374020..85957eafb 100644
--- a/packages/compress-stringify/python/itkwasm-compress-stringify/pyproject.toml
+++ b/packages/compress-stringify/python/itkwasm-compress-stringify/pyproject.toml
@@ -6,7 +6,8 @@ build-backend = "hatchling.build"
 name = "itkwasm-compress-stringify"
 readme = "README.md"
 license = "Apache-2.0"
-dynamic = ["version", "description"]
+dynamic = ["version"]
+description = "Zstandard compression and decompression and base64 encoding and decoding in WebAssembly."
 classifiers = [
   "License :: OSI Approved :: Apache Software License",
   "Programming Language :: Python",
diff --git a/packages/dicom/python/itkwasm-dicom/pyproject.toml b/packages/dicom/python/itkwasm-dicom/pyproject.toml
index db80d1731..8a0889d42 100644
--- a/packages/dicom/python/itkwasm-dicom/pyproject.toml
+++ b/packages/dicom/python/itkwasm-dicom/pyproject.toml
@@ -6,7 +6,8 @@ build-backend = "hatchling.build"
 name = "itkwasm-dicom"
 readme = "README.md"
 license = "Apache-2.0"
-dynamic = ["version", "description"]
+dynamic = ["version"]
+description = "Read files and images related to DICOM file format."
 classifiers = [
   "License :: OSI Approved :: Apache Software License",
   "Programming Language :: Python",
diff --git a/src/bindgen/python/package-py-project-toml.js b/src/bindgen/python/package-py-project-toml.js
index 767c74837..74018803e 100644
--- a/src/bindgen/python/package-py-project-toml.js
+++ b/src/bindgen/python/package-py-project-toml.js
@@ -7,6 +7,7 @@ function packagePyProjectToml(packageName, packageDir, bindgenPyPackage, options
   let pyProjectToml = fs.readFileSync(bindgenResource('template.pyproject.toml'), {encoding:'utf8', flag:'r'})
   pyProjectToml = pyProjectToml.replaceAll('@bindgenPackageName@', packageName)
   const repository = options.repository ?? 'https://github.com/InsightSoftwareConsortium/itk-wasm'
+  const bindgenPackageDescription = options.packageDescription
   let bindgenKeywords = ''
   let bindgenDependencies = ''
   let bindgenHatchEnvDependencies = ''
@@ -49,6 +50,7 @@ serve = [
   pyProjectToml = pyProjectToml.replaceAll('@bindgenHatchEnvScripts@', bindgenHatchEnvScripts)
   pyProjectToml = pyProjectToml.replaceAll('@bindgenProjectRepository@', repository)
   pyProjectToml = pyProjectToml.replaceAll('@bindgenPyPackage@', bindgenPyPackage)
+  pyProjectToml = pyProjectToml.replaceAll('@bindgenPackageDescription@', bindgenPackageDescription)
   const pyProjectTomlPath = path.join(packageDir, 'pyproject.toml')
   if (!fs.existsSync(pyProjectTomlPath)) {
     fs.writeFileSync(pyProjectTomlPath, pyProjectToml)
diff --git a/src/bindgen/python/resources/template.pyproject.toml b/src/bindgen/python/resources/template.pyproject.toml
index e93e7f14f..ea53d1d95 100644
--- a/src/bindgen/python/resources/template.pyproject.toml
+++ b/src/bindgen/python/resources/template.pyproject.toml
@@ -6,7 +6,8 @@ build-backend = "hatchling.build"
 name = "@bindgenPackageName@"
 readme = "README.md"
 license = "Apache-2.0"
-dynamic = ["version", "description"]
+dynamic = ["version"]
+description = "@bindgenPackageDescription@"
 classifiers = [
   "License :: OSI Approved :: Apache Software License",
   "Programming Language :: Python",