diff --git a/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/__init__.py b/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/__init__.py
index 9f8a84c22..287c25999 100644
--- a/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/__init__.py
+++ b/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/__init__.py
@@ -1,6 +1,7 @@
 """itkwasm-image-io-wasi: Input and output for scientific and medical image file formats. WASI implementation."""
 
 from .read_image import read_image, imread
+from .write_image import write_image, imwrite
 
 from .bio_rad_read_image import bio_rad_read_image
 from .bio_rad_write_image import bio_rad_write_image
diff --git a/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/write_image.py b/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/write_image.py
new file mode 100644
index 000000000..2e2da1e60
--- /dev/null
+++ b/packages/image-io/python/itkwasm-image-io-wasi/itkwasm_image_io_wasi/write_image.py
@@ -0,0 +1,69 @@
+import os
+import importlib
+from pathlib import Path
+from typing import Optional, Union
+
+from itkwasm import Image, PixelTypes, IntTypes, FloatTypes, cast_image
+
+from .extension_to_image_io import extension_to_image_io
+from .image_io_index import image_io_index
+
+def write_image(
+    image: Image,
+    serialized_image: os.PathLike,
+    information_only: bool = False,
+    use_compression: bool = False,
+) -> None:
+    """Write an itk-wasm Image to an image file format.
+
+    :param image: Input image
+    :type  image: Image
+
+    :param serialized_image: Output image serialized in the file format.
+    :type  serialized_image: str
+
+    :param information_only: Only write image metadata -- do not write pixel data.
+    :type  information_only: bool
+
+    :param use_compression: Use compression in the written file
+    :type  use_compression: bool
+
+    :param serialized_image: Input image serialized in the file format
+    :type  serialized_image: os.PathLike
+    """
+    extension = ''.join(Path(serialized_image).suffixes)
+
+    io = None
+    if extension in extension_to_image_io:
+        func = f"{extension_to_image_io[extension]}_write_image"
+        mod_name = f"itkwasm_image_io_wasi.{func}"
+        mod = importlib.import_module(mod_name)
+        io = getattr(mod, func)
+    else:
+        for ioname in image_io_index:
+            func = f"{ioname}_write_image"
+            mod_name = f"itkwasm_image_io_wasi.{func}"
+            mod = importlib.import_module(mod_name)
+            io = getattr(mod, func)
+            could_write = io(image, serialized_image, information_only=information_only, use_compression=use_compression)
+            if could_write:
+                return
+
+    if io is None:
+        raise RuntimeError(f"Could not find an image writer for {extension}")
+
+    could_write = io(image, serialized_image, information_only=information_only, use_compression=use_compression)
+    if not could_write:
+        raise RuntimeError(f"Could not write {serialized_image}")
+
+def imwrite(
+    image: Image,
+    serialized_image: os.PathLike,
+    information_only: bool = False,
+    use_compression: bool = False,
+) -> None:
+    return write_image(image, serialized_image, information_only=information_only, use_compression=use_compression)
+
+imwrite.__doc__ = f"""{write_image.__doc__}
+    Alias for write_image.
+    """
\ No newline at end of file
diff --git a/packages/image-io/python/itkwasm-image-io-wasi/tests/test_read_write_image.py b/packages/image-io/python/itkwasm-image-io-wasi/tests/test_read_write_image.py
index 38c882774..2b50a991c 100644
--- a/packages/image-io/python/itkwasm-image-io-wasi/tests/test_read_write_image.py
+++ b/packages/image-io/python/itkwasm-image-io-wasi/tests/test_read_write_image.py
@@ -2,7 +2,7 @@
 
 from itkwasm import PixelTypes, IntTypes
 
-from itkwasm_image_io_wasi import read_image, imread
+from itkwasm_image_io_wasi import read_image, imread, write_image, imwrite
 
 from .common import test_input_path, test_output_path
 
@@ -44,15 +44,19 @@ def test_imread():
     verify_image(image)
 
 def test_write_image():
-    pass
-    return
-    could_read, image = png_read_image(test_input_file_path)
-    assert could_read
+    image = read_image(test_input_file_path)
+
+    use_compression = False
+    write_image(image, test_output_file_path, use_compression=use_compression)
+
+    image = read_image(test_output_file_path)
+    verify_image(image)
+
+def test_imwrite():
+    image = imread(test_input_file_path)
 
     use_compression = False
-    could_write = png_write_image(image, test_output_file_path, use_compression)
-    assert could_write
+    imwrite(image, test_output_file_path, use_compression=use_compression)
 
-    could_read, image = png_read_image(test_output_file_path)
-    assert could_read
+    image = imread(test_output_file_path)
     verify_image(image)