diff --git a/automatic/cellprofiler/cellprofiler.nuspec b/automatic/cellprofiler/cellprofiler.nuspec
index a8398580e..f81bc68f8 100644
--- a/automatic/cellprofiler/cellprofiler.nuspec
+++ b/automatic/cellprofiler/cellprofiler.nuspec
@@ -3,7 +3,7 @@
 <package xmlns="http://schemas.microsoft.com/packaging/2015/06/nuspec.xsd">
   <metadata>
     <id>cellprofiler</id>
-    <version>4.2.0</version>
+    <version>4.2.1</version>
     <packageSourceUrl>https://github.com/ITS-Unibas/chocolatey-community-packages/tree/master/automatic/cellprofiler</packageSourceUrl>
     <owners>ITS-Unibas</owners>
     <!-- ============================== -->
diff --git a/automatic/cellprofiler/tools/chocolateyinstall.ps1 b/automatic/cellprofiler/tools/chocolateyinstall.ps1
index 2e75e5187..e5a615741 100644
--- a/automatic/cellprofiler/tools/chocolateyinstall.ps1
+++ b/automatic/cellprofiler/tools/chocolateyinstall.ps1
@@ -7,11 +7,11 @@ $packageArgs = @{
   packageName    = $packageName
   unzipLocation  = $toolsDir
   fileType       = 'EXE'
-  url            = 'https://cellprofiler-releases.s3.amazonaws.com/CellProfiler-Windows-4.2.0.exe'
+  url            = 'https://cellprofiler-releases.s3.amazonaws.com/CellProfiler-Windows-4.2.1.exe'
   silentArgs     = '/VERYSILENT /NORESTART /NOCANCEL'
   validExitCodes = @(0)
   softwareName   = 'Cellprofiler*'
-  checksum       = '05e3af13d6548673b5cd2be840d9b48b962719794834d6b601ba06ec38c71937'
+  checksum       = '1dab0892787b03d500eb4ac96848561459faace9588b22ab1bc08d4aaa6f6687'
   checksumType   = 'sha256'
 }