diff --git a/Formula/python@3.8.rb b/Formula/python@3.8.rb
index b86be6060f04..c7d04a9453ff 100644
--- a/Formula/python@3.8.rb
+++ b/Formula/python@3.8.rb
@@ -4,7 +4,7 @@ class PythonAT38 < Formula
   url "https://www.python.org/ftp/python/3.8.7/Python-3.8.7.tar.xz"
   sha256 "ddcc1df16bb5b87aa42ec5d20a5b902f2d088caa269b28e01590f97a798ec50a"
   license "Python-2.0"
-  revision 1
+  revision 2
 
   livecheck do
     url "https://www.python.org/ftp/python/"
@@ -36,6 +36,7 @@ class PythonAT38 < Formula
   depends_on "openssl@1.1"
   depends_on "readline"
   depends_on "sqlite"
+  depends_on "tcl-tk"
   depends_on "xz"
 
   uses_from_macos "bzip2"
@@ -117,14 +118,13 @@ def install
       # The setup.py looks at "-isysroot" to get the sysroot (and not at --sysroot)
       cflags  << "-isysroot #{MacOS.sdk_path}"
       ldflags << "-isysroot #{MacOS.sdk_path}"
-      # For the Xlib.h, Python needs this header dir with the system Tk
-      # Yep, this needs the absolute path where zlib needed a path relative
-      # to the SDK.
-      cflags << "-isystem #{MacOS.sdk_path}/System/Library/Frameworks/Tk.framework/Versions/8.5/Headers"
     end
     # Avoid linking to libgcc https://mail.python.org/pipermail/python-dev/2012-February/116205.html
     args << "MACOSX_DEPLOYMENT_TARGET=#{MacOS.version}"
 
+    args << "--with-tcltk-includes=-I#{Formula["tcl-tk"].opt_include}"
+    args << "--with-tcltk-libs=-L#{Formula["tcl-tk"].opt_lib} -ltcl8.6 -ltk8.6"
+
     # We want our readline! This is just to outsmart the detection code,
     # superenv makes cc always find includes/libs!
     inreplace "setup.py",
@@ -259,9 +259,9 @@ def post_install
 
     # Help distutils find brewed stuff when building extensions
     include_dirs = [HOMEBREW_PREFIX/"include", Formula["openssl@1.1"].opt_include,
-                    Formula["sqlite"].opt_include]
+                    Formula["sqlite"].opt_include], Formula["tcl-tk"].opt_include
     library_dirs = [HOMEBREW_PREFIX/"lib", Formula["openssl@1.1"].opt_lib,
-                    Formula["sqlite"].opt_lib]
+                    Formula["sqlite"].opt_lib], Formula["tcl-tk"].opt_lib
 
     cfg = prefix/"Frameworks/Python.framework/Versions/#{xy}/lib/python#{xy}/distutils/distutils.cfg"
 
@@ -343,10 +343,7 @@ def caveats
     # Check if some other modules import. Then the linked libs are working.
     system "#{bin}/python#{xy}", "-c", "import _gdbm"
     system "#{bin}/python#{xy}", "-c", "import zlib"
-
-    # Temporary failure on macOS 11.1 due to https://bugs.python.org/issue42480
-    # Reenable unconditionnaly once Apple fixes the Tcl/Tk issue
-    system "#{bin}/python#{xy}", "-c", "import tkinter; root = tkinter.Tk()" if MacOS.full_version < "11.1"
+    system "#{bin}/python#{xy}", "-c", "import tkinter; root = tkinter.Tk()"
 
     system bin/"pip3", "list", "--format=columns"
   end