diff --git a/README.md b/README.md
index 06deb308f69..3039fb4a341 100644
--- a/README.md
+++ b/README.md
@@ -93,6 +93,10 @@ $ docker-compose up -d -V --remove-orphans --force-recreate
 $ yarn services
 ```
 
+> **Note**
+> The `couchbase`, `grpc` and `oracledb` instrumentations rely on native modules
+> that do not compile on ARM64 devices (for example M1/M2 Mac) - their tests
+> cannot be run locally on these devices.
 
 ### Unit Tests
 
diff --git a/scripts/install_plugin_modules.js b/scripts/install_plugin_modules.js
index ccfde83f81e..c14867a4439 100644
--- a/scripts/install_plugin_modules.js
+++ b/scripts/install_plugin_modules.js
@@ -1,6 +1,7 @@
 'use strict'
 
 const fs = require('fs')
+const os = require('node:os')
 const path = require('path')
 const crypto = require('crypto')
 const semver = require('semver')
@@ -11,6 +12,7 @@ const externals = require('../packages/dd-trace/test/plugins/externals')
 
 const requirePackageJsonPath = require.resolve('../packages/dd-trace/src/require-package-json')
 
+const excludeList = os.arch() === 'arm64' ? ['couchbase', 'grpc', 'oracledb'] : []
 const workspaces = new Set()
 const versionLists = {}
 const deps = {}
@@ -42,6 +44,8 @@ async function run () {
   assertFolder()
   await assertVersions()
   assertWorkspace()
+  // Some native addon packages rely on libraries that are not supported on ARM64
+  excludeList.forEach(pkg => delete workspaces[pkg])
   install()
 }
 
@@ -197,7 +201,7 @@ function install () {
 
 function addFolder (name, version) {
   const basename = [name, version].filter(val => val).join('@')
-  workspaces.add(basename)
+  if (!excludeList.includes(name)) workspaces.add(basename)
 }
 
 function folder (name, version) {