WisecondorX reference file

[smruti241]

Hii,
I have a small doubt. if I have 100 files then we will make reference.npz files. But again I will get 100 files then should I have to create reference.npz file for those 100 files or total 200 files? Will it affect my z-score or affect my results? Secondly, will WisecondorX help in analyzing all chromosomal aneuploidy including sex chromosome aneuploidy, microdeletions and single gene disorder? If yes for sex chromosome aneuploidy, then what about microdeletions and single gene disorder? is there any tools or software for this? Please answer to this questions.