diff --git a/yarn-project/end-to-end/src/e2e_card_game.test.ts b/yarn-project/end-to-end/src/e2e_card_game.test.ts
index 2632ef1a648..84d52e8cca4 100644
--- a/yarn-project/end-to-end/src/e2e_card_game.test.ts
+++ b/yarn-project/end-to-end/src/e2e_card_game.test.ts
@@ -1,4 +1,10 @@
-import { AccountWallet, AztecAddress, Wallet, getSandboxAccountsWallets } from '@aztec/aztec.js';
+import {
+  AccountWallet,
+  AztecAddress,
+  Wallet,
+  deployInitialSandboxAccounts,
+  getSandboxAccountsWallets,
+} from '@aztec/aztec.js';
 import { DebugLogger } from '@aztec/foundation/log';
 import { CardGameContract } from '@aztec/noir-contracts/types';
 import { PXE } from '@aztec/types';
@@ -7,6 +13,8 @@ import { setup } from './fixtures/utils.js';
 
 /* eslint-disable camelcase */
 
+const { PXE_URL } = process.env;
+
 interface Card {
   points: bigint;
   strength: bigint;
@@ -65,7 +73,14 @@ describe('e2e_card_game', () => {
     // Card stats are derived from the users' private keys, so to get consistent values, we set up the
     // initial sandbox accounts that always use the same private keys, instead of random ones.
     ({ pxe, logger, teardown } = await setup(0));
-    wallets = await getSandboxAccountsWallets(pxe);
+
+    // Get pre-deployed account wallets if we're running against sandbox.
+    if (PXE_URL) {
+      wallets = await getSandboxAccountsWallets(pxe);
+    } else {
+      // Deploy initial wallets if we're NOT running against sandbox.
+      wallets = await Promise.all((await deployInitialSandboxAccounts(pxe)).map(a => a.account.getWallet()));
+    }
     [firstPlayerWallet, secondPlayerWallet, thirdPlayerWallet] = wallets;
     [firstPlayer, secondPlayer, thirdPlayer] = wallets.map(a => a.getAddress());
     await deployContract();
diff --git a/yarn-project/end-to-end/src/e2e_cli.test.ts b/yarn-project/end-to-end/src/e2e_cli.test.ts
index 681fc0b2adb..bb3d0a11d71 100644
--- a/yarn-project/end-to-end/src/e2e_cli.test.ts
+++ b/yarn-project/end-to-end/src/e2e_cli.test.ts
@@ -1,23 +1,38 @@
+import { startHttpRpcServer } from '@aztec/aztec-sandbox';
 import { PXE, createDebugLogger } from '@aztec/aztec.js';
+import { createPXERpcServer } from '@aztec/pxe';
 
 import { setup as e2eSetup } from './fixtures/utils.js';
 import { cliTestSuite } from './shared/cli.js';
 
-const { PXE_URL } = process.env;
+const HTTP_PORT = 9009;
+let RPC_URL = `http://localhost:${HTTP_PORT}`;
 const debug = createDebugLogger('aztec:e2e_cli');
 
+let http: ReturnType<typeof startHttpRpcServer>;
 let pxe: PXE;
 let teardown: () => Promise<void>;
 
+// Use Sandbox PXE URL if we're running against sandbox
+const { PXE_URL } = process.env;
+if (PXE_URL) {
+  RPC_URL = PXE_URL;
+}
+
 const testSetup = async () => {
   const context = await e2eSetup(2);
   debug(`Environment set up`);
   ({ pxe, teardown } = context);
+  if (!PXE_URL) {
+    http = startHttpRpcServer(pxe, createPXERpcServer, HTTP_PORT);
+    debug(`HTTP RPC server started in port ${HTTP_PORT}`);
+  }
   return pxe;
 };
 
 const testCleanup = async () => {
+  http?.close();
   await teardown();
 };
 
-cliTestSuite('E2E CLI Test', testSetup, testCleanup, createDebugLogger('aztec:e2e_cli'), PXE_URL);
+cliTestSuite('E2E CLI Test', testSetup, testCleanup, createDebugLogger('aztec:e2e_cli'), RPC_URL);
diff --git a/yarn-project/end-to-end/src/e2e_multiple_accounts_1_enc_key.test.ts b/yarn-project/end-to-end/src/e2e_multiple_accounts_1_enc_key.test.ts
index 9e8f9d1b139..85cca3baeb0 100644
--- a/yarn-project/end-to-end/src/e2e_multiple_accounts_1_enc_key.test.ts
+++ b/yarn-project/end-to-end/src/e2e_multiple_accounts_1_enc_key.test.ts
@@ -10,10 +10,12 @@ import {
 import { Fr, GrumpkinScalar } from '@aztec/foundation/fields';
 import { DebugLogger } from '@aztec/foundation/log';
 import { TokenContract } from '@aztec/noir-contracts/types';
-import { AztecNode, PXE, TxStatus } from '@aztec/types';
+import { AztecNode, CompleteAddress, PXE, TxStatus } from '@aztec/types';
 
 import { expectsNumOfEncryptedLogsInTheLastBlockToBe, setup } from './fixtures/utils.js';
 
+const { PXE_URL } = process.env;
+
 describe('e2e_multiple_accounts_1_enc_key', () => {
   let aztecNode: AztecNode | undefined;
   let pxe: PXE;
@@ -45,12 +47,18 @@ describe('e2e_multiple_accounts_1_enc_key', () => {
 
     // Verify that all accounts use the same encryption key
     const encryptionPublicKey = await generatePublicKey(encryptionPrivateKey);
+
     // Disregard sandbox accounts
-    const sandBoxWallets = await getSandboxAccountsWallets(pxe);
-    const allAccounts = await pxe.getRegisteredAccounts();
-    const keyAccounts = allAccounts.filter(
-      acc => !sandBoxWallets.map(wlt => wlt.getAddress().toString()).includes(acc.address.toString()),
-    );
+    let keyAccounts: CompleteAddress[];
+    if (PXE_URL) {
+      const sandBoxWallets = await getSandboxAccountsWallets(pxe);
+      const allAccounts = await pxe.getRegisteredAccounts();
+      keyAccounts = allAccounts.filter(
+        acc => !sandBoxWallets.map(wlt => wlt.getAddress().toString()).includes(acc.address.toString()),
+      );
+    } else {
+      keyAccounts = await pxe.getRegisteredAccounts();
+    }
     for (const account of keyAccounts) {
       expect(account.publicKey).toEqual(encryptionPublicKey);
     }